Pot-Bellied Mice Point to Obesity Enzyme

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Science  07 Dec 2001:
Vol. 294, Issue 5549, pp. 2071-2072
DOI: 10.1126/science.294.5549.2071a

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People who carry excess fat around their waists are known to be more prone to obesity-related maladies than their equally overweight counterparts who pack weight around their hips, but no one has been able to explain the connection. Now on page 2166, researchers suggest a reason for the disease-body type relationship and a possible new target for treatment. The culprit is an obscure enzyme that works to recycle a steroid stress hormone called cortisol.