Epithelial Cell Differentiation--a Mather of Choice

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Science  07 Dec 2001:
Vol. 294, Issue 5549, pp. 2115-2116
DOI: 10.1126/science.1067751

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The epithelium of the gut is composed of four different cell types that differentiate from a common progenitor stem cell pool in the crypts. But what are the signals that influence progenitor cells to adopt one of four possible cell fates? In a Perspective, van den Brink et al. discuss new findings ( Yang et al.) that identify the transcription factor, Math1, as an important mediator of cell fate choice by gut epithelial progenitor cells.