PerspectiveSTEM CELLS

PTEN--Coupling Tumor Suppression to Stem Cells?

See allHide authors and affiliations

Science  07 Dec 2001:
Vol. 294, Issue 5549, pp. 2116-2118
DOI: 10.1126/science.1067931

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Mutations in the tumor suppressor protein PTEN are found in many different tumors. As Penninger and Woodgett discuss in their Perspective, new findings implicate PTEN in the control of neuronal cell size and in the proliferation and self-renewal of neuronal stem cells ( Groszer et al.). This surprising finding may yield both research and therapeutic benefits.