Report

Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the Pten Tumor Suppressor Gene in Vivo

Science  07 Dec 2001:
Vol. 294, Issue 5549, pp. 2186-2189
DOI: 10.1126/science.1065518

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

The mechanisms controlling neural stem cell proliferation are poorly understood. Here we demonstrate that the PTEN tumor suppressor plays an important role in regulating neural stem/progenitor cells in vivo and in vitro. Mice lacking PTEN exhibited enlarged, histoarchitecturally abnormal brains, which resulted from increased cell proliferation, decreased cell death, and enlarged cell size. Neurosphere cultures revealed a greater proliferation capacity for tripotent Pten –/– central nervous system stem/progenitor cells, which can be attributed, at least in part, to a shortened cell cycle. However, cell fate commitments of the progenitors were largely undisturbed. Our results suggest that PTEN negatively regulates neural stem cell proliferation.

  • * Present address: Epigenomics AG, Kastanienallee 24, 10435 Berlin, Germany.

  • To whom correspondence should be addressed. E-mail: xliu{at}mednet.ucla.edu, hwu{at}mednet.ucla.edu

View Full Text

Cited By...