News of the WeekCARCINOGENIC BACTERIA

Cracking Gut Bugs' Cell-Skewing Strategy

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Science  14 Dec 2001:
Vol. 294, Issue 5550, pp. 2269
DOI: 10.1126/science.294.5550.2269a

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Summary

Researchers have learned a lot about how Helicobacter pylori digs into the wall of the stomach to cause ulcers, but they knew little about how the bug makes cells malignant--until now. In a study published online by Science this week (www.sciencexpress.org), molecular oncologists have shown exactly how one of the bacterium's proteins hijacks a signaling pathway in stomach cells, pushing them to change shape and allowing them to move--an early step toward turning cells cancerous.