Research Article

The Genome of the Natural Genetic Engineer Agrobacterium tumefaciens C58

Science  14 Dec 2001:
Vol. 294, Issue 5550, pp. 2317-2323
DOI: 10.1126/science.1066804

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Abstract

The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids. Extensive orthology and nucleotide colinearity between the genomes of A. tumefaciens and the plant symbiont Sinorhizobium meliloti suggest a recent evolutionary divergence. Their similarities include metabolic, transport, and regulatory systems that promote survival in the highly competitive rhizosphere; differences are apparent in their genome structure and virulence gene complement. Availability of the A. tumefaciens sequence will facilitate investigations into the molecular basis of pathogenesis and the evolutionary divergence of pathogenic and symbiotic lifestyles.

  • * Present address: Department of Pathology, University of Washington, Box 357470, Seattle, WA 98195, USA.

  • Present address: Gene Function & Target Validation, Celltech R&D Inc., Bothell, WA 98021, USA.

  • Present address: Department of Plant Pathology, Kansas State University, 113 Waters Hall, Manhattan, KS 66506, USA.

  • § To whom correspondence should be addressed. E-mail: gnester{at}u.washington.edu

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