Coenzymes and Radicals

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Science  21 Dec 2001:
Vol. 294, Issue 5551, pp. 2489-2490
DOI: 10.1126/science.1067916

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Organic radicals play an important role in many enzymatic reactions, but as Frey explains in his Perspective, information about their structure is hard to come by. He highlights the report by Chabrière et al., who have crystallized the enzyme pyruvate:ferredoxin oxidoreductase with the intermediate radical form of hydroxyethylidene-thiamine pyrophosphate bound to its active site. The structure of the radical provides important clues to its electronic structure.