Switching Partners in a Regulatory Tango

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Science  21 Dec 2001:
Vol. 294, Issue 5551, pp. 2497-2498
DOI: 10.1126/science.1067622

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The coactivator CBP/p300 cooperates with the enzyme CARM1 to boost the activity of the nuclear hormone receptor transcription factors. But what is the relationship between CBP/p300 and CARM1? As Nishioka and Reinberg explain in their Perspective, new work reveals that CARM1 regulates the availability of CBP/p300 by methylating the KIX domain of this coactivator.