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Construction and Analysis of a Human-Chimpanzee Comparative Clone Map

Science  04 Jan 2002:
Vol. 295, Issue 5552, pp. 131-134
DOI: 10.1126/science.1065199

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Abstract

The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.

  • * These authors form the International Consortium for the Sequencing of Chimpanzee Chromosome 22.

  • To whom correspondence should be addressed. E-mail: afujiyam{at}gsc.riken.go.jp, watanabe{at}gsc.riken.go.jp, hattori{at}gsc.riken.go.jp, sakaki{at}gsc.riken.go.jp

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