Molecular Basis of Mossy Fiber LTP

Science  04 Jan 2002:
Vol. 295, Issue 5552, pp. 9
DOI: 10.1126/science.295.5552.9n

Long-term potentiation (LTP) at hippocampal mossy fiber synapses is distinct from most other forms of LTP. Mellor et al. (p. 143) found that the hyperpolarization-activated mixed cation current Ih unexpectedly plays an important role. Calcium entry into the hippocampal granule cells during repetitive stimulation activates a calcium/calmodulin sensitive adenylate cyclase. The subsequent rise in cyclic adenosine monophosphate activates protein kinase A, which leads to increases in Ih. The resulting depolarization causes an enhancement of mossy fiber synaptic transmission.

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