Report

Remarkably Selective Iridium Catalysts for the Elaboration of Aromatic C-H Bonds

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Science  11 Jan 2002:
Vol. 295, Issue 5553, pp. 305-308
DOI: 10.1126/science.1067074

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Abstract

Arylboron compounds have intriguing properties and are important building blocks for chemical synthesis. A family of Ir catalysts now enables the direct synthesis of arylboron compounds from aromatic hydrocarbons and boranes under “solventless” conditions. The Ir catalysts are highly selective for C–H activation and do not interfere with subsequent in situ transformations, including Pd-mediated cross-couplings with aryl halides. By virtue of their favorable activities and exceptional selectivities, these Ir catalysts impart the synthetic versatility of arylboron reagents to C–H bonds in aromatic and heteroaromatic hydrocarbons.

  • * To whom correspondence should be addressed. E-mail: smithmil{at}msu.edu

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