Report

Role of Diacylglycerol in PKD Recruitment to the TGN and Protein Transport to the Plasma Membrane

Science  11 Jan 2002:
Vol. 295, Issue 5553, pp. 325-328
DOI: 10.1126/science.1066759

You are currently viewing the abstract.

View Full Text
As a service to the community, AAAS/Science has made this article free with registration.

Abstract

Protein kinase D (PKD) is a cytosolic serine-threonine kinase that binds to the trans-Golgi network (TGN) and regulates the fission of transport carriers specifically destined to the cell surface. PKD was found to bind diacylglycerol (DAG), and this binding was necessary for its recruitment to the TGN. Reducing cellular levels of DAG inhibited PKD recruitment and blocked protein transport from the TGN to the cell surface. Thus, a DAG-dependent, PKD-mediated signaling regulates the formation of transport carriers from the TGN in mammalian cells.

  • * To whom correspondence should be addressed. E-mail: malhotra{at}biomail.ucsd.edu

View Full Text

Cited By...