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Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet

Science  11 Jan 2002:
Vol. 295, Issue 5553, pp. 336-338
DOI: 10.1126/science.1065544

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Abstract

Human asthma is associated with airway infiltration by T helper 2 (TH2) lymphocytes. We observed reduced expression of the TH1 transcription factor, T-bet, in T cells from airways of patients with asthma compared with that in T cells from airways of nonasthmatic patients, suggesting that loss of T-bet might be associated with asthma. Mice with a targeted deletion of the T-bet gene and severe combined immunodeficient mice receiving CD4+ cells from T-bet knockout mice spontaneously demonstrated multiple physiological and inflammatory features characteristic of asthma. Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma.

  • * To whom correspondence should be addressed. E-mail lglimche{at}hsph.harvard.edu

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