News of the WeekCell Biology

Stripping the Nucleolus Down to Its Proteins

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Science  18 Jan 2002:
Vol. 295, Issue 5554, pp. 422
DOI: 10.1126/science.295.5554.422a

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Scientists have identified 271 proteins in a compartment of the cell nucleus called the nucleolus--a first step toward fully deciphering this organelle, a critical element in the construction of ribosomes, which go on to make proteins. With scientists now debating the nucleolus's role in additional functions, including cell cycle regulation and gene silencing, this starter list of proteins--30% of which are uncharacterized--offers plenty to chew on.