DATABASE: Kinase Connection

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Science  25 Jan 2002:
Vol. 295, Issue 5555, pp. 591
DOI: 10.1126/science.295.5555.591d

A huge extended family of regulatory proteins, the kinases help govern a multitude of cellular activities—from lipid metabolism to angiogenesis, the growth of new blood vessels. You'll find a growing collection of information and tools for analyzing these ubiquitous enzymes at the Protein Kinase Resource, a database of sequence and structural information from the San Diego Supercomputer Center. The curators are revamping an old site that hadn't been updated in 3 years, and they are hoping that visitors will pitch in by submitting content, links, and other resources. However, the site already boasts several useful tools, such as an alignment feature that allows you to graphically compare the sequences and structures of multiple proteins. The site also offers community resources, such as a directory of researchers and a list of upcoming meetings, as well as a series of tutorials on kinases and their functions, including their involvement in cancer.

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