News of the WeekGene Therapy

Blood Test Flags Agent in Death of Penn Subject

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Science  25 Jan 2002:
Vol. 295, Issue 5555, pp. 604-605
DOI: 10.1126/science.295.5555.604b

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Exactly what killed Jesse Gelsinger, the first volunteer to die in a human gene therapy trial, remains a mystery, but last week researchers in Germany fingered a feature of his immune system as a prime suspect. They also believe that a simple blood test might be able to prevent similar tragedies in future gene therapy trials.