News FocusCancer Research

Taking Garbage In, Tossing Cancer Out?

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Science  25 Jan 2002:
Vol. 295, Issue 5555, pp. 612-613
DOI: 10.1126/science.295.5555.612

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Cancer drugs, with few exceptions, go after predictable targets: DNA replication (cisplatin), microtubules (Taxol), growth signaling pathways (Gleevec), and angiogenesis (for example, endostatin). Now a new class of compounds that work in a novel way--blocking the cell's garbage disposal, or proteasome--is showing promise in clinical trials, although their mechanism of action is complex and still poorly understood.