A Cargo Receptor Mystery APParently Solved?

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Science  01 Feb 2002:
Vol. 295, Issue 5556, pp. 805-807
DOI: 10.1126/science.1069661

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It is still not clear what causes the deposition of sticky amyloid b peptides in the brains of patients with Alzheimer's disease. In a Perspective, Sangram Sisodia offers a provocative look at a new theory that postulates the involvement of defective axonal transport of cargo-laden membrane vesicles in the etiology of this neurodegenerative disease.