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A Bioartificial Liver--State of the Art

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Science  08 Feb 2002:
Vol. 295, Issue 5557, pp. 1005-1009
DOI: 10.1126/science.1068660

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End-stage liver disease is treated by liver transplantation, but donor organ shortages remain a serious problem. This has prompted the design of bioartificial liver devices to “bridge” patients until they either recover or receive a liver transplant. In these devices, patient plasma is circulated extracorporeally through a bioreactor that houses liver cells (hepatocytes) sandwiched between artificial plates or capillaries.

  • * To whom correspondence should be addressed. E-mail: a.j.strain{at}bham.ac.uk

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