Cracking the Secrets of Aging

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Science  08 Feb 2002:
Vol. 295, Issue 5557, pp. 1033
DOI: 10.1126/science.295.5557.1033

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Theories about how to define aging abound, including the accumulation of cell damage and the stiffening of tissue with formation of sugar-protein bonds. Another is the progressive shortening of telomeres, the tips of chromosomes, as cells divide. Scientists are still not even sure whether aging is in fact a unitary phenomenon. Meanwhile, the life-extending effect of calorie restriction offers researchers tantalizing clues.