Under Pressure

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Science  08 Feb 2002:
Vol. 295, Issue 5557, pp. 983-984
DOI: 10.1126/science.1069950

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Glaucoma, a disease that results in progressive loss of peripheral vision, is a principal cause of blindness worldwide. In their Perspective, Friedman and Walter describe new findings ( Rezaie et al.) that identify mutations in a gene encoding the optineurin protein in a significant number of patients with primary open-angle glaucoma. This discovery may help us to better understand what causes glaucoma, eventually leading to therapeutic interventions to treat this tragic disease.