Mediator Meets Morpheus

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Science  08 Feb 2002:
Vol. 295, Issue 5557, pp. 984-985
DOI: 10.1126/science.1069485

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Deciphering how the numerous coactivators of transcription work is a formidable task. In his Perspective, Meisterernst discusses the implications of new findings ( Taatjes et al.) that describe the structures of the ARC-L and CRSP coactivator complexes and their interactions with transcriptional activators.