One AID to Unite Them All

See allHide authors and affiliations

Science  15 Feb 2002:
Vol. 295, Issue 5558, pp. 1244-1245
DOI: 10.1126/science.1070023

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


By creating an extremely diverse antibody repertoire, B cells protect the body against numerous infectious pathogens. Generation of this antibody repertoire depends on immunoglobulin gene modification events driven by four different molecular processes: V(D)J recombination, somatic hypermutation, class switch recombination, and gene conversion. The enzyme AID (activation-induced cytidine deaminase) is known to be involved in somatic hypermutation and class switch recombination. In their Perspective, Fugmann and Schatz explain that AID is also essential for gene conversion ( Arakawa et al.) and discuss how AID could operate in these three quite different processes.