PerspectiveSignal Transduction

Scaffolding Proteins--More Than Meets the Eye

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Science  15 Feb 2002:
Vol. 295, Issue 5558, pp. 1249-1250
DOI: 10.1126/science.1069828

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The accepted pathway of MAPK activation is through a three kinase phosphorelay arrangement. However, as Johnson explains in his Perspective, new work has established an alternative way for a MAPK called p38a to be activated ( Ge et al.). Apparently, a scaffolding protein called TAB1 that is devoid of any known catalytic activity is able to interact with p38a, inducing its autophosphorylation and consequent activation.