The Immunological Synapse--a Multitasking System

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Science  22 Feb 2002:
Vol. 295, Issue 5559, pp. 1479-1480
DOI: 10.1126/science.1069896

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The immunological synapse, the interface between the T cell and antigen-presenting cell (APC), is thought to be important for enhancing and sustaining signaling by the T cell receptor after it has engaged antigenic peptide on the APC surface. In a Perspective, van der Merwe and Davis discuss new findings ( Lee et al.) demonstrating that T cell receptor signaling takes place well before formation of the immunological synapse, suggesting that this dynamic structure may have other functions.