A Moving Story

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Science  22 Feb 2002:
Vol. 295, Issue 5559, pp. 1480-1481
DOI: 10.1126/science.1069823

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Many protein structures are known with high accuracy, but much less is known about their dynamics. In his Perspective, Falke highlights the report by Eisenmesser et al., who have used a nuclear magnetic resonance approach to follow protein transition state movements during catalysis in the enzyme cyclophilin A. The method should generate a wealth of new information about motions in working enzymes.