Report

Role of Nucleoporin Induction in Releasing an mRNA Nuclear Export Block

See allHide authors and affiliations

Science  22 Feb 2002:
Vol. 295, Issue 5559, pp. 1523-1525
DOI: 10.1126/science.1067861

You are currently viewing the abstract.

View Full Text

Abstract

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC). Some NPC components, such as the nucleoporins (Nups) Nup98 and Nup96, are also associated with the nuclear interior. Nup98 is a target of the vesicular stomatitis virus (VSV) matrix (M) protein–mediated inhibition of messenger RNA (mRNA) nuclear export. Here, Nup98 and Nup96 were found to be up-regulated by interferon (IFN). M protein–mediated inhibition of mRNA nuclear export was reversed when cells were treated with IFN-γ or transfected with a complementary DNA (cDNA) encoding Nup98 and Nup96. Thus, increased Nup98 and Nup96 expression constitutes an IFN-mediated mechanism that reverses M protein–mediated inhibition of gene expression.

  • * To whom correspondence should be addressed. E-mail: blobel{at}rockvax.rockefeller.edu

View Full Text