Does BDNF Have Pre- or Postsynaptic Targets?

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Science  01 Mar 2002:
Vol. 295, Issue 5560, pp. 1651-1653
DOI: 10.1126/science.1070163

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A type of synaptic plasticity in the brain called long-term potentiation (LTP) is thought to form the molecular basis of learning and memory. In a Perspective, Manabe discusses new findings ( Kovalchuk et al.) showing brain-derived neurotropic factor modulates LTP by binding to TrkB receptors on the postsynaptic neuron.