Special Reviews

Systems Biology: A Brief Overview

Science  01 Mar 2002:
Vol. 295, Issue 5560, pp. 1662-1664
DOI: 10.1126/science.1069492

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Abstract

To understand biology at the system level, we must examine the structure and dynamics of cellular and organismal function, rather than the characteristics of isolated parts of a cell or organism. Properties of systems, such as robustness, emerge as central issues, and understanding these properties may have an impact on the future of medicine. However, many breakthroughs in experimental devices, advanced software, and analytical methods are required before the achievements of systems biology can live up to their much-touted potential.

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