Special Reviews

A Genomic Regulatory Network for Development

Science  01 Mar 2002:
Vol. 295, Issue 5560, pp. 1669-1678
DOI: 10.1126/science.1069883

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Abstract

Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

  • * To whom correspondence should be addressed. E-mail: davidson{at}caltech.edu

  • Present address: European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB101 1SD, UK.

  • Present address: Altera European Technology Centre, Holmers Farm Way, High Wycombe, Buckinghamshire HP12 4XF, UK.

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