Cell Biology

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Science  08 Mar 2002:
Vol. 295, Issue 5561, pp. 1795
DOI: 10.1126/science.295.5561.1795c

SUMO-1 is a recently discovered ubiquitin-like protein modifier that can be linked to various substrates. One of these is the protein RanGAP1, which activates the GTPase Ran (which cycles through GTP- and GDP-bound states) during nuclear transport and cell division. Dasso et al. find that sumoylation (addition of SUMO) was critical for the correct localization of RanGAP1 during mitosis. A mutated form of RanGAP1 that could not be sumoylated no longer associated with mitotic spindles. The spindle association of RanGAP1 also appeared to involve an interaction with a nuclear pore protein, RanBP2, that enhances sumoylation, as shown by Pichler et al. Thus, sumoylation of RanGAP1 is important for the spatial regulation of this key protein during progression through mitosis. — SMH

J. Cell Biol. 156, 595 (2002); Cell108, 109 (2002).

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