A Perfect Mismatch

See allHide authors and affiliations

Science  15 Mar 2002:
Vol. 295, Issue 5562, pp. 2029-2031
DOI: 10.1126/science.1070538

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


For patients with leukemia that is refractory to chemotherapy, bone marrow or stem cell transplantation is often the only hope. In his Perspective, Kärre discusses important new findings ( Ruggeri et al.) revealing that a favorable mismatch in HLA molecules between donor and recipient tissues enables natural killer cells in the graft to reduce host rejection of the transplant while promoting attack of residual leukemia cells, thus increasing the likelihood that the transplant will succeed.