PerspectiveMolecular Biology

Skiing Toward Nonstop mRNA Decay

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Science  22 Mar 2002:
Vol. 295, Issue 5563, pp. 2221-2222
DOI: 10.1126/science.1071285

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Prokaryotic and eukaryotic cells have quality assurance mechanisms that operate during translation to prevent buildup of deleterious protein products. In her Perspective, Maquat discusses new work ( Frischmeyer et al. and van Hoof et al.) that describes how eukaryotic cells identify and degrade messenger RNA that lacks a termination codon.