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Adaptive Immune Response of Vγ2Vδ2+ T Cells During Mycobacterial Infections

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Science  22 Mar 2002:
Vol. 295, Issue 5563, pp. 2255-2258
DOI: 10.1126/science.1068819

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Abstract

To examine the role of T cell receptor (TCR) in γδ T cells in adaptive immunity, a macaque model was used to follow Vγ2Vδ2+ T cell responses to mycobacterial infections. These phosphoantigen-specific γδ T cells displayed major expansion during Mycobacterium bovis Bacille Calmette-Guérin (BCG) infection and a clear memory-type response after BCG reinfection. Primary and recall expansions of Vγ2Vδ2+ T cells were also seen during Mycobacterium tuberculosis infection of naı̈ve and BCG-vaccinated macaques, respectively. This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vγ2Vδ2+ T cells may contribute to adaptive immunity to mycobacterial infections.

  • * To whom correspondence should be addressed. E-mail, zchen{at}caregroup.harvard.edu

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