Defining the "S" in SERMs

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Science  29 Mar 2002:
Vol. 295, Issue 5564, pp. 2380-2381
DOI: 10.1126/science.1070442

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Tamoxifen, which opposes estrogen action in some tissues while mimicking its action in others, has reduced breast cancer mortality significantly during the past decade. In their Perspective, Katzenellenbogen and Katzenellenbogen discuss new findings (Shang and Brown) that unravel the molecular basis of tamoxifen's differential activity in breast and uterine tissue.