Pathogen Surveillance--the Flies Have It

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Science  12 Apr 2002:
Vol. 296, Issue 5566, pp. 273-275
DOI: 10.1126/science.1071208

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Discoveries about the innate immune systems of flies and mammals reveal startling similarities between these two systems. In a Perspective, Khush et al., discuss new findings ( Choe et al.) showing a key role for pattern recognition receptors of the peptidoglycan recognition protein family in the induction of appropriate immune responses in the fruit fly.