Special Viewpoints

The Danger Model: A Renewed Sense of Self

Science  12 Apr 2002:
Vol. 296, Issue 5566, pp. 301-305
DOI: 10.1126/science.1071059

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Abstract

For over 50 years immunologists have based their thoughts, experiments, and clinical treatments on the idea that the immune system functions by making a distinction between self and nonself. Although this paradigm has often served us well, years of detailed examination have revealed a number of inherent problems. This Viewpoint outlines a model of immunity based on the idea that the immune system is more concerned with entities that do damage than with those that are foreign.

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