Proteasome Parts at Gene Promoters

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Science  19 Apr 2002:
Vol. 296, Issue 5567, pp. 479-481
DOI: 10.1126/science.1071270

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The proteasome is a garbage disposal unit in eukaryotic cells that degrades proteins tagged with ubiquitin molecules. In their Perspective, Ottosen and colleagues discuss new findings ( Gonzalez et al.) revealing that certain components of the proteasome may be involved in processes other than protein degradation. Six ATPases in the base section of the 19 S proteasomal subcomplex are recruited to sites of gene activation, suggesting that they may be involved in transcription.