When the Host Is Smarter Than the Parasite

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Science  19 Apr 2002:
Vol. 296, Issue 5567, pp. 482-483
DOI: 10.1126/science.1071206

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The wily malaria parasite has become resistant to many affordable frontline antimalarial drugs, and new drug targets are desperately needed. Reporting in a Perspective on new work ( Zhang et al.), Goldberg suggests that we look for drug targets among proteins that are shared by the host and parasite but whose synthesis is regulated in a different way.