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Maneuvering in the Complex Path from Genotype to Phenotype

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Science  26 Apr 2002:
Vol. 296, Issue 5568, pp. 701-703
DOI: 10.1126/science.1070534

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Human disease phenotypes are controlled not only by genes but by lawful self-organizing networks that display system-wide dynamics. These networks range from metabolic pathways to signaling pathways that regulate hormone action. When perturbed, networks alter their output of matter and energy which, depending on the environmental context, can produce either a pathological or a normal phenotype. Study of the dynamics of these networks by approaches such as metabolic control analysis may provide new insights into the pathogenesis and treatment of complex diseases.

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