Lower Closing Costs

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Science  03 May 2002:
Vol. 296, Issue 5569, pp. 809
DOI: 10.1126/science.296.5569.809a

Among the antibiotics that are of interest in combating Gram-positive bacterial strains, especially those strains that are vancomycin-resistant, is ramoplanin. This cyclic depsipeptide, which bears lipid and glycogen side chains, forms a 49-membered ring and thus presents a formidable challenge for total synthesis. Jiang et al. now report that the A2 form of ramoplanin without its sugar side chains can be made from three smaller subunits. Although one might have anticipated low yields for the final ring-closure step, the formation of β sheet-like structure and the closure at the D-amine terminus lead to a yield of about 90% for this final step.—PDS

J. Am. Chem. Soc. 10.1021/ja020237q (2002).

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