A Pathogen Receptor on Natural Killer Cells

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Science  17 May 2002:
Vol. 296, Issue 5571, pp. 1248-1249
DOI: 10.1126/science.1072447

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Natural killer (NK) cells of the innate immune system lack receptors tailored, through genetic reshuffling, to recognize an enormous array of antigens. However, they are readily able to recognize bacterial, viral, and tumor cell molecules. In their Perspective, Vivier and Biron discuss new work ( Arase et al.) that identifies an activating Ly49 receptor on mouse NK cells that recognizes a viral protein and protects mice against MCMV infection.