Genomic Priorities in Aging

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Science  17 May 2002:
Vol. 296, Issue 5571, pp. 1250-1251
DOI: 10.1126/science.1071808

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Many theories of aging have been proposed, but one of the most enduring is that expounding accumulated damage to the DNA as the root cause. In their Perspective, Hasty and Vijg comment on recent findings ( de Boer et al.) in a mouse model of a human disease that point to imperfect repair of DNA damage over a lifetime as an important contributor to the cellular deterioration associated with aging.