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Induction and Suppression of RNA Silencing by an Animal Virus

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Science  17 May 2002:
Vol. 296, Issue 5571, pp. 1319-1321
DOI: 10.1126/science.1070948

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Abstract

RNA silencing is a sequence-specific RNA degradation mechanism that is operational in plants and animals. Here, we show that flock house virus (FHV) is both an initiator and a target of RNA silencing in Drosophila host cells and that FHV infection requires suppression of RNA silencing by an FHV-encoded protein, B2. These findings establish RNA silencing as an adaptive antiviral defense in animal cells. B2 also inhibits RNA silencing in transgenic plants, providing evidence for a conserved RNA silencing pathway in the plant and animal kingdoms.

  • * To whom correspondence should be addressed. E-mail: shou-wei.ding{at}ucr.edu

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