Understanding Disease Cell by Cell

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Science  17 May 2002:
Vol. 296, Issue 5571, pp. 1329-1330
DOI: 10.1126/science.296.5571.1329

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The study of disease one cell at a time is being facilitated by advances in the field of tissue dissection. Using laser-guided microdissection tools coupled with a microscope, researchers can begin to understand molecular alterations in pure populations of cells. This essay discusses microdissection for an historical perspective and describes new approaches to the problem.