HLA Leaves Its Footprints on HIV

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Science  24 May 2002:
Vol. 296, Issue 5572, pp. 1410-1411
DOI: 10.1126/science.1072492

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That HIV is able to escape the antibody response of the human immune system is well established. In a Perspective, McMichael and Klenerman explain new work ( Moore et al.) providing evidence that HIV is able to mutate crucial epitopes, thus enabling the virus also to evade the host CTL immune response.