Visualizing Chromatin Dynamics in Interphase Nuclei

See allHide authors and affiliations

Science  24 May 2002:
Vol. 296, Issue 5572, pp. 1412-1416
DOI: 10.1126/science.1067703

You are currently viewing the abstract.

View Full Text


Real-time fluorescence microscopy has emerged as a powerful tool for examining chromatin dynamics. The initial lesson is that much of the genome, particularly in yeast, is highly dynamic. Its movement within the interphase nucleus is correlated with metabolic activity. Nonetheless, the nucleus is an organelle with conserved rules of organization. Determining the distribution and regulation of mobile domains in interphase chromosomes, and characterizing sites of anchorage, will undoubtedly shed new light on the function of nuclear order.

View Full Text