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Induction of Cachexia in Mice by Systemically Administered Myostatin

Science  24 May 2002:
Vol. 296, Issue 5572, pp. 1486-1488
DOI: 10.1126/science.1069525

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Abstract

Mice and cattle with genetic deficiencies in myostatin exhibit dramatic increases in skeletal muscle mass, suggesting that myostatin normally suppresses muscle growth. Whether this increased muscling results from prenatal or postnatal lack of myostatin activity is unknown. Here we show that myostatin circulates in the blood of adult mice in a latent form that can be activated by acid treatment. Systemic overexpression of myostatin in adult mice was found to induce profound muscle and fat loss analogous to that seen in human cachexia syndromes. These data indicate that myostatin acts systemically in adult animals and may be a useful pharmacologic target in clinical settings such as cachexia, where muscle growth is desired.

  • * Present address: Department of Surgery, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box SURG, Rochester, NY 14642, USA.

  • Present address: Torrey Mesa Research Institute, 3115 Merryfield Row, San Diego, CA 92121, USA.

  • To whom correspondence should be addressed. E-mail: sjlee{at}jhmi.edu

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