Cell Biology

Divide and Rule

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Science  31 May 2002:
Vol. 296, Issue 5573, pp. 1573
DOI: 10.1126/science.296.5573.1573a

Cell division requires the allocation of two sets of chromosomes to daughter cells and also the physical separation (cytokinesis) of the two daughter cells. In an effort to understand the detailed mechanisms involved in cytokinesis and to develop a system in which new components in the machinery of cytokinesis can be identified, Somma et al. have used RNA interference (RNAi) to disrupt a variety of proteins in cultured Drosophila cells. Ablation of specific gene products led to distinctive phenotypes: for example, blocking the assembly of the central spindle, inhibiting the accumulation of actin at the equator of the cell, and interfering with the assembly and disassembly of the contractile ring. Having established the reliable recognition of phenotypes, future work will focus on the identification of genes involved in this fundamental cellular process. — SMH

Mol. Biol. Cell. 10.1091/mbc.01-12-0589 (2002).

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