In Search of a Kinder, Gentler Vaccine

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Science  31 May 2002:
Vol. 296, Issue 5573, pp. 1594
DOI: 10.1126/science.296.5573.1594

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The traditional smallpox vaccine, a virus called vaccinia that's harvested from the pustules on the skin of infected calves, is very effective--and also quite dangerous. So current talk of vaccinating thousands or millions makes some experts rather nervous. But it's not yet clear what the alternatives are.

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